Document Type : Original Article
Authors
1
Department of Environmental Science, Faculty of Science, Suez University
2
Department of Marine Science, Faculty of Science, Suez Canal University
3
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt.
Abstract
This research aimed at screening in vivo antioxidant and anti-inflammatory activities as well as in vitro
antimicrobial and cytotoxic activities in Codium tomentosum, Ulva lactuca and Hypnea musciformis,
collected form the Suez Canal, Egypt. Samples were cleaned from epiphytes, washed, air dried and
powdered. All the methanol/methylene chloride crude extracts showed a marked antioxidant effect
compared to the reference drug vitamin E on alloxan induced diabetic rats and Hypnea musciformis (red
algae) was the most potent (60.18%). Also, it showed the maximum anti-inflammatory activity in
carrageenan-induced rat paw edema. Both extracts of H. musciformis and U. lactuca showed a wide
spectrum antibacterial activity, and the highest activity appeared against Klebsiella pneumoniae (clinical
culture). Moreover, all the crude extracts showed a promising cytotoxic activity (> 70%) against liver
(HEPG2) and prostrate (PC3) cancer cell lines using Sulpho-Rhodamine-B (SRB) assay. The ethyl acetate
fractions of U. lactuca, C. tomentosum and H. musciformis were significantly enhanced in HEPG2 with
IC50 (12.8, 24.5 and 17.8 μg/ml), respectively, compared to the control doxorubicin. Such biological
activities might be attributed to the presence of phenols, flavonoids, and tannins, as active constituents in
all algal extracts. Besides Alkaloids observed in U. lactuca and H. musciformis, as well as saponins from
U. lactuca.
Keywords
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