Post-vaccination studies on mice vaccinated against uropathogenic Escherichia coli

Document Type : Original Article

Authors

1 Faculty of Science, Suez Canal University, Egypt

2 Faculty of Veterinary Medicine, Suez Canal University, Egypt

3 Faculty of Agriculture, Suez Canal University, Egypt.

4 Faculty of Science, Suez Canal University, Egypt Faculty of Science, Ibb university, Yemen

Abstract

Vaccination is one of the most important strategies for fighting infection. The efficiency of vaccination is
determined by many tests that evaluate the immune response vaccine elicit. Here Uropathogenic E. coli
vaccines were evaluated by challenge test, indirect haemagglutination test, histopathology, haematology
and biochemistry measurements. The results indicate to the benefit of inactivated polyvalent whole cell
vaccine and adjuvant-use in immunopotentiation of vaccine. Many measures were used as a good
indication and correlated to effectiveness of vaccine as post–vaccination antibody titer, total leukocytic
count, neutrophil percent and total protein. Also the histopathology results for dead mice give clear clue
to the interpretation of challenge test results.

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